1,4-Dioxane → 6-[3-(3,4-Difluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-N-(tetrahydro-pyran-4-yl)-nicotinamide
Reaction equation
[CH3:12][O:13][C:14]([c:15]1[cH:16][n:17][c:18]([O:21][CH2:22][c:23]2[c:24](-[c:30]3[cH:31][c:32]([F:37])[c:33]([F:36])[cH:34][cH:35]3)[n:25][o:26][c:27]2[CH2:28][OH:29])[cH:19][cH:20]1)=[O:38].[CH3:1][Al:2]([CH3:3])[CH3:4].[NH2:5][CH:6]1[CH2:7][CH2:8][O:9][CH2:10][CH2:11]1.[O:39]1[CH2:40][CH2:41][O:42][CH2:43][CH2:44]1>>[NH:5]([CH:6]1[CH2:7][CH2:8][O:9][CH2:10][CH2:11]1)[C:14](=[O:13])[c:15]1[cH:16][n:17][c:18]([O:21][CH2:22][c:23]2[c:24](-[c:30]3[cH:31][c:32]([F:37])[c:33]([F:36])[cH:34][cH:35]3)[n:25][o:26][c:27]2[CH2:28][OH:29])[cH:19][cH:20]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-2abe72e9fc2546318ffe6f0260661a5f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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