Carbonate Ion → Tert-butyl 4-(6-(6-chloro-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)piperidine-1-carboxylate
Reaction equation
[Br:1][c:2]1[c:3](=[O:10])[n:4]([CH3:9])[n:5][c:6]([Cl:8])[cH:7]1.[C:73](=[O:74])([O-:75])[O-:76].[Cs+:77].[Cs+:78].[NH2:11][c:12]1[cH:13][cH:14][c:15]([CH:18]2[CH2:19][CH2:20][N:21]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:22][CH2:23]2)[cH:16][n:17]1.[O:105]=[C:106]([CH:107]=[CH:108][c:109]1[cH:110][cH:111][cH:112][cH:113][cH:114]1)[CH:115]=[CH:116][c:117]1[cH:118][cH:119][cH:120][cH:121][cH:122]1.[O:123]=[C:124]([CH:125]=[CH:126][c:127]1[cH:128][cH:129][cH:130][cH:131][cH:132]1)[CH:133]=[CH:134][c:135]1[cH:136][cH:137][cH:138][cH:139][cH:140]1.[O:79]1[CH2:80][CH2:81][O:82][CH2:83][CH2:84]1.[O:87]=[C:88]([CH:89]=[CH:90][c:91]1[cH:92][cH:93][cH:94][cH:95][cH:96]1)[CH:97]=[CH:98][c:99]1[cH:100][cH:101][cH:102][cH:103][cH:104]1.[Pd:85].[Pd:86].[c:31]1([P:32]([c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[c:39]2[c:40]3[c:64]([cH:65][cH:66][cH:67]2)[C:61]([CH3:62])([CH3:63])[c:43]2[c:42]([c:47]([P:48]([c:49]4[cH:50][cH:51][cH:52][cH:53][cH:54]4)[c:55]4[cH:56][cH:57][cH:58][cH:59][cH:60]4)[cH:46][cH:45][cH:44]2)[O:41]3)[cH:68][cH:69][cH:70][cH:71][cH:72]1>>[c:2]1([NH:11][c:12]2[cH:13][cH:14][c:15]([CH:18]3[CH2:19][CH2:20][N:21]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:22][CH2:23]3)[cH:16][n:17]2)[c:3](=[O:10])[n:4]([CH3:9])[n:5][c:6]([Cl:8])[cH:7]1Participants
9
Reactant 8
HCID 19660Carbonate Ion
HCID 23938Palladium2×
HCID 312751,4-Dioxane
HCID 95417Dibenzylidene acetone3×
HCID 104967Cesium cation2×
HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)
HCID 49839963tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate
HCID 592164744-Bromo-6-chloro-2-methyl-2,3-dihydropyridazin-3-oneProduct 1
Sources & evidence
- ORD record
- ord-4e43d50170314948ad604653f2ea2306
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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