Dichloromethane → 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(2-(N-methyl-N-t-butoxycarbonylamino)ethoxy)quinazoline
Reaction equation
[CH2:66]([Cl:67])[Cl:68].[CH3:1][N:2]([C:3](=[O:4])[O:5][C:6]([CH3:7])([CH3:8])[CH3:9])[CH2:10][CH2:11][OH:12].[Cl:13][c:14]1[cH:15][c:16]([F:34])[c:17]([NH:18][c:19]2[n:20][cH:21][n:22][c:23]3[cH:24][c:25]([OH:31])[c:26]([O:29][CH3:30])[cH:27][c:28]23)[cH:32][cH:33]1.[O:54]=[C:55]([O:56][CH2:57][CH3:58])[N:59]=[N:60][C:61]([O:62][CH2:63][CH3:64])=[O:65].[c:35]1([P:36]([c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[cH:49][cH:50][cH:51][cH:52][cH:53]1>>[CH3:1][N:2]([C:3](=[O:4])[O:5][C:6]([CH3:7])([CH3:8])[CH3:9])[CH2:10][CH2:11][O:12][c:25]1[cH:24][c:23]2[n:22][cH:21][n:20][c:19]([NH:18][c:17]3[c:16]([F:34])[cH:15][c:14]([Cl:13])[cH:33][cH:32]3)[c:28]2[cH:27][c:26]1[O:29][CH3:30]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-6f7057b25dcc48f6970119dc214fa590
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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