Hydrochloric Acid → 1'-(pyrimidin-2-ylmethyl)spiro[3,7-dihydro-2H-furo[2,3-g][1,4]benzodioxine-8,3'-indole]-2'-one

HRID 1134713Notes

Reaction equation

HRID 1134713 reaction equation
[Cl:10][CH2:11][c:12]1[c:13]([C:14]([F:15])([F:16])[F:17])[n:18][cH:19][cH:20][cH:21]1.[Cl:2][CH2:3][c:4]1[n:5][cH:6][cH:7][cH:8][n:9]1.[ClH:1].[NH:22]1[C:23](=[O:43])[C:24]2([CH2:25][O:26][c:27]3[cH:28][c:29]4[c:30]([cH:35][c:36]32)[O:31][CH2:32][CH2:33][O:34]4)[c:37]2[cH:38][cH:39][cH:40][cH:41][c:42]21.[NH:44]1[c:45]2[c:46]([cH:47][cH:48][cH:49][cH:50]2)[C:51]2([c:52]3[c:53]([cH:54][c:55]4[c:60]([cH:61]3)[O:59][CH2:58][CH2:57][O:56]4)[O:62][CH2:63]2)[C:64]1=[O:65]>>[CH2:3]([c:4]1[n:5][cH:6][cH:7][cH:8][n:9]1)[N:22]1[C:23](=[O:43])[C:24]2([CH2:25][O:26][c:27]3[cH:28][c:29]4[c:30]([cH:35][c:36]32)[O:31][CH2:32][CH2:33][O:34]4)[c:37]2[cH:38][cH:39][cH:40][cH:41][c:42]21

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 128773712-(Chloromethyl)pyrimidineHCID 534172573-(Chloromethyl)-2-(trifluoromethyl)pyridineHCID 58224164Spiro[furo[2,3-g]-1,4-benzodioxin-8(7H),3'-[3H]indol]-2'(1'H)-one, 2,3-dihydro2×

Product 1

HCID 461948531'-(pyrimidin-2-ylmethyl)spiro[3,7-dihydro-2H-furo[2,3-g][1,4]benzodioxine-8,3'-indole]-2'-one

Sources & evidence

ORD record
ord-921d8174ceb54131ae9ce341476ca876
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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