Water → 2,6-Difluoro-3-[4'-(4-methoxy-phenyl)-[2,5']bithiazolyl-2'-ylmethoxy]-benzamide

HRID 1135124Notes

Reaction equation

HRID 1135124 reaction equation
[Br:1][c:2]1[c:3](-[c:20]2[cH:21][cH:22][c:23]([O:26][CH3:27])[cH:24][cH:25]2)[n:4][c:5]([CH2:7][O:8][c:9]2[c:10]([F:19])[c:11]([C:12](=[O:13])[NH2:14])[c:15]([F:18])[cH:16][cH:17]2)[s:6]1.[CH2:28]([Sn:29]([CH2:30][CH2:31][CH2:32][CH3:38])([c:33]1[s:34][cH:35][cH:36][n:37]1)[CH2:39][CH2:40][CH2:41][CH3:42])[CH2:43][CH2:44][CH3:45].[O:47]=[CH:48][N:49]([CH3:50])[CH3:51].[OH2:46].[Pd:52].[c:53]1([PH:54]([c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)([c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[cH:73][cH:74][cH:75][cH:76][cH:77]1>>[c:2]1(-[c:33]2[s:34][cH:35][cH:36][n:37]2)[c:3](-[c:20]2[cH:21][cH:22][c:23]([O:26][CH3:27])[cH:24][cH:25]2)[n:4][c:5]([CH2:7][O:8][c:9]2[c:10]([F:19])[c:11]([C:12](=[O:13])[NH2:14])[c:15]([F:18])[cH:16][cH:17]2)[s:6]1

Participants

7

Reactant 6

HCID 962WaterHCID 6228DimethylformamideHCID 23938PalladiumHCID 27632592-(Tributylstannyl)-1,3-thiazoleHCID 594026583-[5-Bromo-4-(4-methoxy-phenyl)-thiazol-2-ylmethoxy]-2,6-difluoro-benzamideHCID 178420552HCID 178420552, compound

Product 1

HCID 594027082,6-Difluoro-3-[4'-(4-methoxy-phenyl)-[2,5']bithiazolyl-2'-ylmethoxy]-benzamide

Sources & evidence

ORD record
ord-2de911d3a3464150ac7ecba12408893b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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