Dichloromethane → 4-(2-Bromo-1,3-thiazol-5-yl)-7H-pyrrolo[2,3-d]pyrimidine

HRID 113554Notes

Reaction equation

HRID 113554 reaction equation
[Br:1][c:2]1[s:3][c:4](-[c:7]2[c:8]3[c:9]([n:10][cH:11][n:12]2)[n:13]([CH2:16][O:17][CH2:18][CH2:19][Si:20]([CH3:21])([CH3:22])[CH3:23])[cH:14][cH:15]3)[cH:5][n:6]1.[Cl:24][CH2:25][Cl:26].[F:27][C:28]([F:29])([F:30])[C:31]([OH:32])=[O:33]>>[Br:1][c:2]1[s:3][c:4](-[c:7]2[c:8]3[c:9]([n:10][cH:11][n:12]2)[nH:13][cH:14][cH:15]3)[cH:5][n:6]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 574776224-(2-Bromo-1,3-thiazol-5-yl)-7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 574776214-(2-Bromo-1,3-thiazol-5-yl)-7H-pyrrolo[2,3-d]pyrimidine

Sources & evidence

ORD record
ord-8719d07855e3496cafc90e8ff04239bf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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