Water → alpha-(6-Amino-3-pyridinyl)-5-chloro-1-(phenylsulfonyl)-1H-pyrrolo(2,3-b)pyridine-3-methanol

HRID 1136693Notes

Reaction equation

HRID 1136693 reaction equation
[CH2:9]([Li:10])[CH2:11][CH2:12][CH3:13].[Cl:14][Si:15]([CH3:16])([CH3:17])[CH2:18][CH2:19][Si:20]([Cl:21])([CH3:22])[CH3:23].[NH2:1][c:2]1[n:3][cH:4][c:5]([Br:8])[cH:6][cH:7]1.[O:45]1[CH2:46][CH2:47][CH2:48][CH2:49]1.[OH2:50].[c:24]1([S:30](=[O:31])(=[O:32])[n:33]2[cH:34][c:35]([CH:43]=[O:44])[c:36]3[c:37]2[n:38][cH:39][c:40]([Cl:42])[cH:41]3)[cH:25][cH:26][cH:27][cH:28][cH:29]1>>[NH2:1][c:2]1[n:3][cH:4][c:5]([CH:43]([c:35]2[cH:34][n:33]([S:30]([c:24]3[cH:25][cH:26][cH:27][cH:28][cH:29]3)(=[O:31])=[O:32])[c:37]3[c:36]2[cH:41][c:40]([Cl:42])[cH:39][n:38]3)[OH:44])[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 962WaterHCID 8028TetrahydrofuranHCID 706222-Amino-5-bromopyridineHCID 835521,2-Bis(chlorodimethylsilyl)ethaneHCID 497590321H-Pyrrolo[2,3-B]pyridine-3-carboxaldehyde, 5-chloro-1-(phenylsulfonyl)-HCID 178418339Butyllithium

Product 1

HCID 57619405alpha-(6-Amino-3-pyridinyl)-5-chloro-1-(phenylsulfonyl)-1H-pyrrolo(2,3-b)pyridine-3-methanol

Sources & evidence

ORD record
ord-4b4c416469264a459176401c91c69430
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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