Sodium ion → Tert-butyl 6-(6-(6-chloro-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)-2,6-diazaspiro[3.3]heptane-2-carboxylate

HRID 1137255Notes

Reaction equation

HRID 1137255 reaction equation
[Br:22][c:23]1[c:24](=[O:31])[n:25]([CH3:30])[n:26][c:27]([Cl:29])[cH:28]1.[C:32](=[O:33])([O-:34])[O-:35].[Cl:44][CH2:45][Cl:46].[Cs+:36].[Cs+:37].[NH2:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][C:10]3([CH2:11][N:12]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:13]3)[CH2:21]2)[cH:6][n:7]1.[Na+:47].[Na+:48].[O-:49][S:50]([O-:51])(=[O:52])=[O:53].[O:38]1[CH2:39][CH2:40][O:41][CH2:42][CH2:43]1.[O:56]=[C:57]([CH:58]=[CH:59][c:60]1[cH:61][cH:62][cH:63][cH:64][cH:65]1)[CH:66]=[CH:67][c:68]1[cH:69][cH:70][cH:71][cH:72][cH:73]1.[O:74]=[C:75]([CH:76]=[CH:77][c:78]1[cH:79][cH:80][cH:81][cH:82][cH:83]1)[CH:84]=[CH:85][c:86]1[cH:87][cH:88][cH:89][cH:90][cH:91]1.[O:92]=[C:93]([CH:94]=[CH:95][c:96]1[cH:97][cH:98][cH:99][cH:100][cH:101]1)[CH:102]=[CH:103][c:104]1[cH:105][cH:106][cH:107][cH:108][cH:109]1.[Pd:54].[Pd:55]>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][C:10]3([CH2:11][N:12]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:13]3)[CH2:21]2)[cH:6][n:7]1)[c:23]1[c:24](=[O:31])[n:25]([CH3:30])[n:26][c:27]([Cl:29])[cH:28]1

Participants

11

Reactant 10

HCID 923Sodium ion2×HCID 1117Sulfate IonHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 23938Palladium2×HCID 312751,4-DioxaneHCID 95417Dibenzylidene acetone3×HCID 104967Cesium cation2×HCID 592164744-Bromo-6-chloro-2-methyl-2,3-dihydropyridazin-3-oneHCID 66743230Tert-butyl 6-(6-aminopyridin-3-yl)-2,6-diazaspiro[3.3]heptane-2-carboxylate

Product 1

HCID 66742401Tert-butyl 6-(6-(6-chloro-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)-2,6-diazaspiro[3.3]heptane-2-carboxylate

Sources & evidence

ORD record
ord-f070700ce41b4c2c81ea313fb9327d94
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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