Dichloromethane → 4-Methanesulfonyl-6-(piperazin-1-ylmethyl)-3,4-dihydro-2H-benzo[1,4]oxazine

HRID 1137712Notes

Reaction equation

HRID 1137712 reaction equation
[CH3:1][S:2](=[O:3])(=[O:4])[N:5]1[CH2:6][CH2:7][O:8][c:9]2[c:10]1[cH:11][c:12]([CH2:15][N:16]1[CH2:17][CH2:18][N:19]([C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[CH2:20][CH2:21]1)[cH:13][cH:14]2.[Cl:36][CH2:37][Cl:38].[OH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35]>>[CH3:1][S:2](=[O:3])(=[O:4])[N:5]1[CH2:6][CH2:7][O:8][c:9]2[c:10]1[cH:11][c:12]([CH2:15][N:16]1[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1)[cH:13][cH:14]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 86597571tert-Butyl 4-(4-methanesulfonyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)piperazine-1-carboxylate

Product 1

HCID 112091394-Methanesulfonyl-6-(piperazin-1-ylmethyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Sources & evidence

ORD record
ord-920a12fd9743455b9acda129f8bdc5cb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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