Methanol → 3-Methyl-1,6-diazaspiro[3.4]octane-1-carboxylic acid tert-butyl ester

HRID 1137739Notes

Reaction equation

HRID 1137739 reaction equation
[C+4:31].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH3:23])[C:11]12[CH2:12][N:13]([CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[CH2:14][CH2:15]2.[CH3:24][OH:25].[O:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1.[OH-:32].[OH-:34].[OH-:35].[OH-:36].[OH-:37].[OH-:38].[Pd+2:33]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH3:23])[C:11]12[CH2:12][NH:13][CH2:14][CH2:15]2

Participants

7

Reactant 6

HCID 887MethanolHCID 961Hydroxide6×HCID 8028TetrahydrofuranHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 58293367HCID 58293367, compoundHCID 178420935HCID 178420935, compound

Product 1

HCID 582933013-Methyl-1,6-diazaspiro[3.4]octane-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-fd4e1901f2fb42d6b7bd2a7b01230060
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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