Dichloromethane → Tert-butyl 1-(2-(2-hydroxyphenyl)quinazolin-4-yl)piperidin-4-ylcarbamate

HRID 113817Notes

Reaction equation

HRID 113817 reaction equation
[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[Cl:1][c:2]1[n:3][c:4](-[c:12]2[c:13]([OH:18])[cH:14][cH:15][cH:16][cH:17]2)[n:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12.[Cl:40][CH2:41][Cl:42].[NH:19]1[CH2:20][CH2:21][CH:22]([NH:25][C:26]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:32])[CH2:23][CH2:24]1>>[c:2]1([N:19]2[CH2:20][CH2:21][CH:22]([NH:25][C:26]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:32])[CH2:23][CH2:24]2)[n:3][c:4](-[c:12]2[c:13]([OH:18])[cH:14][cH:15][cH:16][cH:17]2)[n:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 7238334-(N-Boc-amino)piperidineHCID 40509562-(4-Chloroquinazolin-2-yl)phenol

Product 1

HCID 136121521Tert-butyl 1-(2-(2-hydroxyphenyl)quinazolin-4-yl)piperidin-4-ylcarbamate

Sources & evidence

ORD record
ord-fb9ba60629bb4ac2bbfe6d93f0a5117f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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