Dimethylformamide → 9-Chloro-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-1,4-benzodiazepine

HRID 1138245Notes

Reaction equation

HRID 1138245 reaction equation
[C:1](=[O:2])([O-:3])[O-:4].[CH2:32]([Cl:33])[Cl:34].[CH3:35][N:36]([CH3:37])[CH:38]=[O:39].[Cl:7][c:8]1[cH:9][cH:10][cH:11][c:12]2[c:18]1[NH:17][C:16](=[O:19])[CH2:15][N:14]=[C:13]2[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1.[Cs+:5].[Cs+:6].[F:26][C:27]([CH2:28][I:29])([F:30])[F:31]>>[Cl:7][c:8]1[cH:9][cH:10][cH:11][c:12]2[c:18]1[N:17]([CH2:28][C:27]([F:26])([F:30])[F:31])[C:16](=[O:19])[CH2:15][N:14]=[C:13]2[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 677091,1,1-Trifluoro-2-iodoethaneHCID 104967Cesium cation2×HCID 184442579-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Product 1

HCID 184442569-Chloro-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-1,4-benzodiazepine

Sources & evidence

ORD record
ord-c7054cbd675442e7aef9a9c275b662f6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…