Water → 2-(4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-yloxy)pyridine

HRID 1138586Notes

Reaction equation

HRID 1138586 reaction equation
[Br:1][c:2]1[n:3][c:4]([O:7][c:8]2[n:9][cH:10][cH:11][cH:12][cH:13]2)[s:5][cH:6]1.[CH2:37]([N:38]([CH:39]([CH3:40])[CH3:41])[CH:42]([CH3:43])[CH3:44])[CH3:45].[CH3:14][O:15][c:16]1[cH:17][cH:18][c:19]([CH2:20][n:21]2[n:22][cH:23][c:24]([B:26]3[O:27][C:28]([CH3:29])([CH3:30])[C:31]([CH3:32])([CH3:33])[O:34]3)[cH:25]2)[cH:35][cH:36]1.[O:47]1[CH2:48][CH2:49][O:50][CH2:51][CH2:52]1.[OH2:46]>>[c:2]1(-[c:24]2[cH:23][n:22][n:21]([CH2:20][c:19]3[cH:18][cH:17][c:16]([O:15][CH3:14])[cH:36][cH:35]3)[cH:25]2)[n:3][c:4]([O:7][c:8]2[n:9][cH:10][cH:11][cH:12][cH:13]2)[s:5][cH:6]1

Participants

6

Reactant 5

HCID 962WaterHCID 312751,4-DioxaneHCID 81531DiisopropylethylamineHCID 534402131-(4-methoxybenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 668718162-(4-Bromothiazol-2-yloxy)pyridine

Product 1

HCID 668891372-(4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-yloxy)pyridine

Sources & evidence

ORD record
ord-d22a9e26a0ea4d5e8c89442c2f78c129
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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