Tetrahydrofuran → (2,4-Difluoro-phenyl)-(3-methoxy-phenyl)-methanol

HRID 1138890Notes

Reaction equation

HRID 1138890 reaction equation
[Br:6][c:7]1[cH:8][c:9]([O:13][CH3:14])[cH:10][cH:11][cH:12]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[F:15][c:16]1[c:17]([CH:18]=[O:19])[cH:20][cH:21][c:22]([F:24])[cH:23]1.[O:25]1[CH2:26][CH2:27][CH2:28][CH2:29]1>>[c:7]1([CH:18]([c:17]2[c:16]([F:15])[cH:23][c:22]([F:24])[cH:21][cH:20]2)[OH:19])[cH:8][c:9]([O:13][CH3:14])[cH:10][cH:11][cH:12]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 169713-BromoanisoleHCID 737702,4-DifluorobenzaldehydeHCID 178418339Butyllithium

Product 1

HCID 17906348(2,4-Difluoro-phenyl)-(3-methoxy-phenyl)-methanol

Sources & evidence

ORD record
ord-27952d44d63c4ad9a2403f278c686f22
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…