Dichloromethane → HCID 178442227, compound

HRID 1138962Notes

Reaction equation

HRID 1138962 reaction equation
[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[Cl:1][c:2]1[c:3]([F:28])[c:4]([CH:8]2[NH:9][CH2:10][CH:11]([CH2:23][C:24]([CH3:25])([CH3:26])[CH3:27])[C:12]2([C:13]#[N:14])[c:15]2[c:16]([F:22])[cH:17][c:18]([Cl:21])[cH:19][cH:20]2)[cH:5][cH:6][cH:7]1.[Cl:29][C:30]([Cl:31])=[O:32].[Cl:52][CH2:53][Cl:54].[nH:40]1[n:41][n:42][n:43][c:44]1-[c:45]1[cH:46][c:47]([NH2:51])[cH:48][cH:49][cH:50]1>>[Cl:1][c:2]1[c:3]([F:28])[c:4]([CH:8]2[N:9]([C:30](=[O:32])[NH:51][c:47]3[cH:46][c:45](-[c:44]4[n:40][n:41][n:42][nH:43]4)[cH:50][cH:49][cH:48]3)[CH2:10][CH:11]([CH2:23][C:24]([CH3:25])([CH3:26])[CH3:27])[C:12]2([C:13]#[N:14])[c:15]2[c:16]([F:22])[cH:17][c:18]([Cl:21])[cH:19][cH:20]2)[cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 6371PhosgeneHCID 8471TriethylamineHCID 67095372rac-(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-4-(2,2-dimethyl-propyl)-pyrrolidine-3-carbonitrileHCID 178507542HCID 178507542, compound

Product 1

HCID 178442227HCID 178442227, compound

Sources & evidence

ORD record
ord-3bd68af70ec048a88a3dae3485a484c3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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