Dichloromethane → tert-Butyl 4-[N-[7-Chloro-3-methyl-2-(4-hydroxypiperidin-1-yl)methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate
Reaction equation
[Cl:1][c:2]1[c:3]([CH2:20][N:21]([CH2:22][C:23]#[CH:24])[c:25]2[cH:26][cH:27][c:28]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[cH:36][cH:37]2)[cH:4][c:5]2[c:6](=[O:19])[n:7]([CH3:18])[c:8]([CH2:12][O:13][S:14]([CH3:15])(=[O:16])=[O:17])[n:9][c:10]2[cH:11]1.[Cl:45][CH2:46][Cl:47].[OH:38][CH:39]1[CH2:40][CH2:41][NH:42][CH2:43][CH2:44]1>>[Cl:1][c:2]1[c:3]([CH2:20][N:21]([CH2:22][C:23]#[CH:24])[c:25]2[cH:26][cH:27][c:28]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[cH:36][cH:37]2)[cH:4][c:5]2[c:6](=[O:19])[n:7]([CH3:18])[c:8]([CH2:12][N:42]3[CH2:41][CH2:40][CH:39]([OH:38])[CH2:44][CH2:43]3)[n:9][c:10]2[cH:11]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-6ee5e6df16f44fd3897ab277a76800b1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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