Potassium Cation → 5-(2-Oxo-pyrrolidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

HRID 1139598Notes

Reaction equation

HRID 1139598 reaction equation
[C:18](=[O:19])([O-:20])[O-:21].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([I:17])[cH:14][c:15]2[CH2:16]1.[Cu:44][I:45].[K+:22].[K+:23].[NH2:24][CH:25]1[CH2:26][CH2:27][CH2:28][CH2:29][CH:30]1[NH2:31].[NH:32]1[C:33](=[O:37])[CH2:34][CH2:35][CH2:36]1.[O:38]1[CH2:39][CH2:40][O:41][CH2:42][CH2:43]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([N:32]3[C:33](=[O:37])[CH2:34][CH2:35][CH2:36]3)[cH:14][c:15]2[CH2:16]1

Participants

8

Reactant 7

HCID 813Potassium Cation2×HCID 46101,2-DiaminocyclohexaneHCID 120252-PyrrolidoneHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 312751,4-DioxaneHCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylate

Product 1

HCID 577535145-(2-Oxo-pyrrolidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-41cfb384cf554ffab63c63de9f3a781e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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