Hydrochloric Acid → 4-{2-[Difluoro(phenyl)acetyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
Reaction equation
[CH3:13][N:14]1[CH2:15][CH2:16][N:17]([c:20]2[n:21][c:22]([NH2:36])[n:23][c:24](-[c:26]3[cH:27][cH:28][c:29]4[c:34]([cH:35]3)[CH2:33][NH:32][CH2:31][CH2:30]4)[cH:25]2)[CH2:18][CH2:19]1.[ClH:37].[F:1][C:2]([C:3](=[O:4])[OH:5])([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[F:12]>>[F:1][C:2]([C:3](=[O:5])[N:32]1[CH2:31][CH2:30][c:29]2[cH:28][cH:27][c:26](-[c:24]3[n:23][c:22]([NH2:36])[n:21][c:20]([N:17]4[CH2:16][CH2:15][N:14]([CH3:13])[CH2:19][CH2:18]4)[cH:25]3)[cH:35][c:34]2[CH2:33]1)([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[F:12]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-4b016998c47c4a3b850138002e483ce5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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