Methanol → tert-Butyl 5-bromo-1-oxo-1,3-dihydro-2H-isoindole-2-carboxylate

HRID 1139797Notes

Reaction equation

HRID 1139797 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[C:7](=[O:11])[NH:6][CH2:5]2.[C:12]([CH3:13])([CH3:14])([CH3:15])[O:16][C:17]([O-:18])=[O:19].[CH3:20][OH:21].[O:22]1[CH2:23][CH2:24][CH2:25][CH2:26]1>>[Br:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[C:7](=[O:11])[N:6]([C:17]([O:16][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:18])[CH2:5]2

Participants

5

Reactant 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 4613278tert-Butyl carbonateHCID 226071195-bromo-2,3-dihydro-1H-isoindol-1-one

Product 1

HCID 23158154tert-Butyl 5-bromo-1-oxo-1,3-dihydro-2H-isoindole-2-carboxylate

Sources & evidence

ORD record
ord-085b89468d9b452fbe520f6bf4173fc3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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