Tetrahydrofuran → 7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

HRID 1139803Notes

Reaction equation

HRID 1139803 reaction equation
[CH2:29]([NH3+:30])[CH2:31][CH2:32][CH3:33].[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][c:12]([O:20][Si:21]([C:22]([CH3:23])([CH3:24])[CH3:25])([CH3:26])[CH3:27])[c:13]([O:18][CH3:19])[cH:14][c:15]2[CH2:16][CH2:17]1.[F-:28].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1>>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][c:12]([OH:20])[c:13]([O:18][CH3:19])[cH:14][c:15]2[CH2:16][CH2:17]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 28179Fluoride IonHCID 3614750ButylammoniumHCID 190420613,4-dihydro-7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxy-2(1H)-isoquinolinecarboxylic acid-1,1-dimethylethyl ester

Product 1

HCID 534153467-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-0e7d0ca10fee4d069a63badf317bbe75
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…