Toluene → (1-{6-[8-Cyclopentyl-6-(1-ethoxy-vinyl)-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-pyridin-3-yl}-pyrrolidin-3-yl)-carbamic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][CH:8]1[CH2:9][N:10]([c:13]2[cH:14][n:15][c:16]([NH:19][c:20]3[n:21][cH:22][c:23]4[c:24]([n:25]3)[n:26]([CH:33]3[CH2:34][CH2:35][CH2:36][CH2:37]3)[c:27](=[O:32])[c:28]([Br:31])[c:29]4[CH3:30])[cH:17][cH:18]2)[CH2:11][CH2:12]1)=[O:38].[CH2:46]([Sn:47]([CH2:48][CH2:49][CH2:50][CH3:56])([C:51](=[CH2:52])[O:53][CH2:54][CH3:55])[CH2:57][CH2:58][CH2:59][CH3:60])[CH2:61][CH2:62][CH3:63].[CH3:39][c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1.[CH:64]([Cl:65])([Cl:66])[Cl:67].[Pd:68].[c:107]1([P:108]([c:109]2[cH:110][cH:111][cH:112][cH:113][cH:114]2)[c:115]2[cH:116][cH:117][cH:118][cH:119][cH:120]2)[cH:121][cH:122][cH:123][cH:124][cH:125]1.[c:126]1([P:127]([c:128]2[cH:129][cH:130][cH:131][cH:132][cH:133]2)[c:134]2[cH:135][cH:136][cH:137][cH:138][cH:139]2)[cH:140][cH:141][cH:142][cH:143][cH:144]1.[c:69]1([P:70]([c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)[c:77]2[cH:78][cH:79][cH:80][cH:81][cH:82]2)[cH:83][cH:84][cH:85][cH:86][cH:87]1.[c:88]1([P:89]([c:90]2[cH:91][cH:92][cH:93][cH:94][cH:95]2)[c:96]2[cH:97][cH:98][cH:99][cH:100][cH:101]2)[cH:102][cH:103][cH:104][cH:105][cH:106]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][CH:8]1[CH2:9][N:10]([c:13]2[cH:14][n:15][c:16]([NH:19][c:20]3[n:21][cH:22][c:23]4[c:24]([n:25]3)[n:26]([CH:33]3[CH2:34][CH2:35][CH2:36][CH2:37]3)[c:27](=[O:32])[c:28]([C:51](=[CH2:52])[O:53][CH2:54][CH3:55])[c:29]4[CH3:30])[cH:17][cH:18]2)[CH2:11][CH2:12]1)=[O:38]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-1bc2e2a6a17f4d93bd6cc9668f049f0e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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