Sodium ion → N-[5-fluoro-7-(3-methoxyprop-1-yn-1-yl)-1,3-benzodioxol-4-yl]-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Reaction equation
[CH3:40][Si:41]([N-:42][Si:43]([CH3:44])([CH3:45])[CH3:46])([CH3:47])[CH3:48].[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]2[cH:7][c:8]([O:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[c:9]([O:12][CH3:13])[cH:10][c:11]12.[F:24][c:25]1[c:26]([NH2:39])[c:27]2[c:28]([c:32]([C:34]#[C:35][CH2:36][O:37][CH3:38])[cH:33]1)[O:29][CH2:30][O:31]2.[Na+:49].[O:50]=[CH:51][N:52]([CH3:53])[CH3:54]>>[c:2]1([NH:39][c:26]2[c:25]([F:24])[cH:33][c:32]([C:34]#[C:35][CH2:36][O:37][CH3:38])[c:28]3[c:27]2[O:31][CH2:30][O:29]3)[n:3][cH:4][n:5][c:6]2[cH:7][c:8]([O:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[c:9]([O:12][CH3:13])[cH:10][c:11]12Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-2a9a6331fa2e44bea02d48b018ea23a4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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