Dimethylformamide → 2-[3-[4-[[5-chloro-4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]-2,5-dimethylphenyl]piperidin-1-yl]-N-methylacetamide

HRID 1140630Notes

Reaction equation

HRID 1140630 reaction equation
[Br:30][CH2:31][C:32](=[O:33])[NH:34][CH3:35].[Cl:1][c:2]1[c:3]([NH:23][c:24]2[n:25][nH:26][c:27]([CH3:29])[cH:28]2)[n:4][c:5]([NH:8][c:9]2[c:10]([CH3:22])[cH:11][c:12]([CH:16]3[CH2:17][NH:18][CH2:19][CH2:20][CH2:21]3)[c:13]([CH3:15])[cH:14]2)[n:6][cH:7]1.[O:36]=[CH:37][N:38]([CH3:39])[CH3:40]>>[Cl:1][c:2]1[c:3]([NH:23][c:24]2[n:25][nH:26][c:27]([CH3:29])[cH:28]2)[n:4][c:5]([NH:8][c:9]2[c:10]([CH3:22])[cH:11][c:12]([CH:16]3[CH2:17][N:18]([CH2:31][C:32](=[O:33])[NH:34][CH3:35])[CH2:19][CH2:20][CH2:21]3)[c:13]([CH3:15])[cH:14]2)[n:6][cH:7]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 154907452-Bromo-N-methylacetamideHCID 446112155-chloro-N2-(2,5-dimethyl-4-(piperidin-3-yl)phenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Product 1

HCID 446123752-[3-[4-[[5-chloro-4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]-2,5-dimethylphenyl]piperidin-1-yl]-N-methylacetamide

Sources & evidence

ORD record
ord-9d352a390083409dbdec9ff254b9e9f4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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