Ammonia → Methyl 2-amino-4-(4-fluorophenyl)-6-isopropylpyrimidine-5-carboxylate

HRID 1141241Notes

Reaction equation

HRID 1141241 reaction equation
[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]([O:21][S:22]([CH3:23])(=[O:24])=[O:25])[n:11][c:12]([CH:18]([CH3:19])[CH3:20])[c:13]2[C:14](=[O:15])[O:16][CH3:17])[cH:6][cH:7]1.[NH3:31].[O:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1.[OH2:32]>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]([NH2:31])[n:11][c:12]([CH:18]([CH3:19])[CH3:20])[c:13]2[C:14](=[O:15])[O:16][CH3:17])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 222AmmoniaHCID 962WaterHCID 8028TetrahydrofuranHCID 179896124-(4-Fluorophenyl)-6-isopropyl-5-methoxycarbonyl-2-methanesulfonyloxypyrimidine

Product 1

HCID 10424248Methyl 2-amino-4-(4-fluorophenyl)-6-isopropylpyrimidine-5-carboxylate

Sources & evidence

ORD record
ord-80cc3d24f4bf43febc12c56737072a52
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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