Water → 4-(7-bromo-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[CH2:9][N:8]([c:12]1[n:13][c:14]([NH2:19])[n:15][c:16]([Cl:18])[cH:17]1)[CH:7]([CH3:20])[CH2:6]2.[C:29]([OH:30])([CH3:31])([CH3:32])[CH3:33].[CH3:21][N:22]1[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]1.[OH2:28]>>[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[CH2:9][N:8]([c:12]1[n:13][c:14]([NH2:19])[n:15][c:16]([N:25]3[CH2:24][CH2:23][N:22]([CH3:21])[CH2:27][CH2:26]3)[cH:17]1)[CH:7]([CH3:20])[CH2:6]2Participants
5
Sources & evidence
- ORD record
- ord-9561ea49924b4a42a61f8a489fc43df1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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