Pyridine → 2-(2,6-Dichloro-4-pyridyl)-5,6-diethyl-3-propargyl-5,6-dihydropyrimidin-4-one

HRID 1141636Notes

Reaction equation

HRID 1141636 reaction equation
[Cl:1][c:2]1[n:3][c:4]([Cl:26])[cH:5][c:6]([C:8]2=[N:9][CH:10]([CH2:24][CH3:25])[C:11]([C:18]([O:19][CH3:20])=[O:21])([CH2:22][CH3:23])[C:12](=[O:17])[N:13]2[CH2:14][C:15]#[CH:16])[cH:7]1.[I-:27].[Li+:28].[cH:29]1[cH:30][cH:31][n:32][cH:33][cH:34]1>>[Cl:1][c:2]1[n:3][c:4]([Cl:26])[cH:5][c:6]([C:8]2=[N:9][CH:10]([CH2:24][CH3:25])[CH:11]([CH2:22][CH3:23])[C:12](=[O:17])[N:13]2[CH2:14][C:15]#[CH:16])[cH:7]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 28486Lithium ionHCID 30165Iodide IonHCID 190485482-(2,6-Dichloro-4-pyridyl)-5,6-diethyl-5-methoxycarbonyl-3-propargyl-5,6-dihydropyrimidin-4-one

Product 1

HCID 190485452-(2,6-Dichloro-4-pyridyl)-5,6-diethyl-3-propargyl-5,6-dihydropyrimidin-4-one

Sources & evidence

ORD record
ord-a9734103b204492da4cbea3c7dc80375
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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