Dichloromethane → 2-[4-(4-Pentanoylamino-phenyl)-thiazol-2-ylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

HRID 1141966Notes

Reaction equation

HRID 1141966 reaction equation
[C:38]([CH2:39][CH2:40][CH2:41][CH3:42])(=[O:43])[Cl:44].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH:12]([C:16]([NH:17][c:18]2[s:19][cH:20][c:21](-[c:23]3[cH:24][cH:25][c:26]([NH2:29])[cH:27][cH:28]3)[n:22]2)=[O:30])[CH2:13][CH2:14][CH2:15]1.[CH2:45]([Cl:46])[Cl:47].[CH3:31][CH2:32][N:33]([CH2:34][CH3:35])[CH2:36][CH3:37]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH:12]([C:16]([NH:17][c:18]2[s:19][cH:20][c:21](-[c:23]3[cH:24][cH:25][c:26]([NH:29][C:38]([CH2:39][CH2:40][CH2:41][CH3:42])=[O:43])[cH:27][cH:28]3)[n:22]2)=[O:30])[CH2:13][CH2:14][CH2:15]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 57849733Benzyl 2-[[4-(4-aminophenyl)-1,3-thiazol-2-yl]carbamoyl]pyrrolidine-1-carboxylate

Product 1

HCID 765827752-[4-(4-Pentanoylamino-phenyl)-thiazol-2-ylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

Sources & evidence

ORD record
ord-d7f15ad2e69e4b61ab4943664c903517
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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