Imidazole → 2-[6-(tert-Butyldimethylsilyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methoxyphenylamine

HRID 1142526Notes

Reaction equation

HRID 1142526 reaction equation
[C:26]([CH3:27])([CH3:28])([CH3:29])[Si:30]([CH3:31])([CH3:32])[Cl:33].[CH3:34][N:35]([CH3:36])[CH:37]=[O:38].[NH2:1][c:2]1[c:3]([CH:10]2[CH2:11][c:12]3[cH:13][cH:14][c:15]([OH:20])[cH:16][c:17]3[CH2:18][CH2:19]2)[cH:4][cH:5][c:6]([O:8][CH3:9])[cH:7]1.[nH:21]1[cH:22][cH:23][n:24][cH:25]1>>[NH2:1][c:2]1[c:3]([CH:10]2[CH2:11][c:12]3[cH:13][cH:14][c:15]([O:20][Si:30]([C:26]([CH3:27])([CH3:28])[CH3:29])([CH3:31])[CH3:32])[cH:16][c:17]3[CH2:18][CH2:19]2)[cH:4][cH:5][c:6]([O:8][CH3:9])[cH:7]1

Participants

5

Reactant 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 28928tert-Butyldimethylsilyl chlorideHCID 230873286-(2-Amino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol

Product 1

HCID 579340442-[6-(tert-Butyldimethylsilyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methoxyphenylamine

Sources & evidence

ORD record
ord-3f137c1c60404c79a6f0cd47f8a04f5b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…