HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 11427Generated: October 25, 2026
Water → 2-[(1-Benzothien-4-yloxy)ethyl]morpholine
https://huagongshe.com/reaction/11427
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzo(b)thiophen-4-ol | HCID 19217 | — |
| Reactant | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| Product | 2-[(1-Benzothien-4-yloxy)ethyl]morpholine | HCID 86760223 | — |
Reaction Steps
4-(2-Chloroethyl)morpholine hydrochloride (0.74 g), 1-benzothiophene-4-ol (0.5 g) and potassium carbonate (1.1 g) in dimethylformamide (15 ml) were heated and stirred at 80° C. for 6 h. After cooling, the mixture was poured into water and extracted twice with ethyl acetate. The combined solvent phase was washed twice with brine, dried (magnesium sulphate) and evaporated to give the product (0.7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07098240B2 |
|---|
| Source dataset | uspto-grants-2006_08 |
|---|
| ORD ID | ord-2afdbf5b452c4473aa1f7b3a5c5a3a04 |
|---|
| Source note | uspto-grants-2006_08 |
|---|
