反应详情

温度

80 °C

4-(2-Chloroethyl)morpholine hydrochloride (0.74 g), 1-benzothiophene-4-ol (0.5 g) and potassium carbonate (1.1 g) in dimethylformamide (15 ml) were heated and stirred at 80° C. for 6 h. After cooling, the mixture was poured into water and extracted twice with ethyl acetate. The combined solvent phase was washed twice with brine, dried (magnesium sulphate) and evaporated to give the product (0.7 g).

1. temperatureAfter cooling
2. extractionextracted twice with ethyl acetate
3. washThe combined solvent phase was washed twice with brine
4. dry with materialdried (magnesium sulphate)
5. customevaporated