Dichloromethane → [1-({4-[(2-Fluoro-4-iodophenyl)amino]-3-thienyl}carbonyl)-3-hydroxyazetidin-3-yl]methyl 2,4,6-tris(1-methylethyl)benzenesulfonate

HRID 1143004Notes

Reaction equation

HRID 1143004 reaction equation
[CH3:46][N:47]([CH3:48])[c:49]1[cH:50][cH:51][n:52][cH:53][cH:54]1.[CH:24]([CH3:25])([CH3:26])[c:27]1[c:28]([S:39](=[O:40])(=[O:41])[Cl:42])[c:29]([CH:36]([CH3:37])[CH3:38])[cH:30][c:31]([CH:33]([CH3:34])[CH3:35])[cH:32]1.[Cl:43][CH2:44][Cl:45].[F:1][c:2]1[c:3]([NH:9][c:10]2[c:11]([C:15](=[O:16])[N:17]3[CH2:18][C:19]([OH:21])([CH2:22][OH:23])[CH2:20]3)[cH:12][s:13][cH:14]2)[cH:4][cH:5][c:6]([I:8])[cH:7]1>>[F:1][c:2]1[c:3]([NH:9][c:10]2[c:11]([C:15](=[O:16])[N:17]3[CH2:18][C:19]([OH:21])([CH2:22][O:23][S:39]([c:28]4[c:27]([CH:24]([CH3:25])[CH3:26])[cH:32][c:31]([CH:33]([CH3:34])[CH3:35])[cH:30][c:29]4[CH:36]([CH3:37])[CH3:38])(=[O:40])=[O:41])[CH2:20]3)[cH:12][s:13][cH:14]2)[cH:4][cH:5][c:6]([I:8])[cH:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 142844-(Dimethylamino)pyridineHCID 810422,4,6-Tris(1-methylethyl)benzenesulfonyl chlorideHCID 670515741-({4-[(2-Fluoro-4-iodophenyl)amino]-3-thienyl}carbonyl)-3-(hydroxymethyl)azetidin-3-ol

Product 1

HCID 86621271[1-({4-[(2-Fluoro-4-iodophenyl)amino]-3-thienyl}carbonyl)-3-hydroxyazetidin-3-yl]methyl 2,4,6-tris(1-methylethyl)benzenesulfonate

Sources & evidence

ORD record
ord-f92a879d251644c68c1a71f28f5ff5fb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…