Dichloromethane → 5-amino-4-[3-[(2-bromoacetyl)amino]phenyl]-N-tert-butyl-2-methylsulfanylquinazoline-6-carboxamide
Reaction equation
[Br:37][CH2:38][C:39](=[O:40])[Cl:41].[CH:28]([N:29]([CH2:30][CH3:31])[CH:32]([CH3:33])[CH3:34])([CH3:35])[CH3:36].[Cl:42][CH2:43][Cl:44].[NH2:1][c:2]1[c:3]2[c:4](-[c:21]3[cH:22][c:23]([NH2:27])[cH:24][cH:25][cH:26]3)[n:5][c:6]([S:19][CH3:20])[n:7][c:8]2[cH:9][cH:10][c:11]1[C:12](=[O:13])[NH:14][C:15]([CH3:16])([CH3:17])[CH3:18]>>[NH2:1][c:2]1[c:3]2[c:4](-[c:21]3[cH:22][c:23]([NH:27][C:39]([CH2:38][Br:37])=[O:40])[cH:24][cH:25][cH:26]3)[n:5][c:6]([S:19][CH3:20])[n:7][c:8]2[cH:9][cH:10][c:11]1[C:12](=[O:13])[NH:14][C:15]([CH3:16])([CH3:17])[CH3:18]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-57fa1a85aa9e4120bd0c9f07c57309a6
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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