Tetrahydrofuran → tert-Butyl 3-(hydroxymethyl)-3-(4-methylbenzyl)piperidine-1-carboxylate

HRID 1143101Notes

Reaction equation

HRID 1143101 reaction equation
[CH2:2]([Al+:3][CH2:4][CH:5]([CH3:6])[CH3:7])[CH:8]([CH3:9])[CH3:10].[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:11][c:12]1[cH:13][cH:14][c:15]([CH2:16][C:17]2([C:30](=[O:31])[O:32][CH2:33][CH3:34])[CH2:18][N:19]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:20][CH2:21][CH2:22]2)[cH:35][cH:36]1.[H-:1]>>[CH3:11][c:12]1[cH:13][cH:14][c:15]([CH2:16][C:17]2([CH2:30][OH:31])[CH2:18][N:19]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:20][CH2:21][CH2:22]2)[cH:35][cH:36]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 166653HydrideHCID 16686348Bis(2-methylpropyl)alumanyliumHCID 229784271-Tert-butyl 3-ethyl 3-(4-methylbenzyl)piperidine-1,3-dicarboxylate

Product 1

HCID 18624164tert-Butyl 3-(hydroxymethyl)-3-(4-methylbenzyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-1cf02b2f47ee48239d47b187191fb73c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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