Dichloromethane → 3-Iodo-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

HRID 1143553Notes

Reaction equation

HRID 1143553 reaction equation
[Cl:1][CH2:2][Cl:3].[Cl:35][CH2:36][Cl:37].[F:4][C:5]([F:6])([F:7])[C:8]([OH:9])=[O:10].[NH2:11][c:12]1[c:13]2[c:14]([n:15][cH:16][n:17]1)[n:18]([CH:22]1[CH2:23][CH2:24][N:25]([C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[CH2:26][CH2:27]1)[n:19][c:20]2[I:21]>>[NH2:11][c:12]1[c:13]2[c:14]([n:15][cH:16][n:17]1)[n:18]([CH:22]1[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]1)[n:19][c:20]2[I:21]

Participants

4

Reactant 3

HCID 6344Dichloromethane2×HCID 6422Trifluoroacetic acidHCID 22346822tert-Butyl 4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

Product 1

HCID 223466933-Iodo-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Sources & evidence

ORD record
ord-e6349b6702534290a6071b5596f2aedc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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