Dimethylformamide → tert-butyl 4-[(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]-4-hydroxy-1-piperidinecarboxylate

HRID 1143634Notes

Reaction equation

HRID 1143634 reaction equation
[C:27](=[O:28])([O-:29])[O-:30].[CH3:33][N:34]([CH3:35])[CH:36]=[O:37].[Cs+:31].[Cs+:32].[I:1][c:2]1[n:3][nH:4][c:5]2[n:6][cH:7][n:8][c:9]([NH2:11])[c:10]12.[O:12]1[CH2:13][C:14]12[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:18][CH2:19]2>>[I:1][c:2]1[n:3][n:4]([CH2:13][C:14]2([OH:12])[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:18][CH2:19]2)[c:5]2[n:6][cH:7][n:8][c:9]([NH2:11])[c:10]12

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 22135564tert-Butyl 1-oxa-6-azaspiro(2.5)octane-6-carboxylateHCID 178508725HCID 178508725, compound

Product 1

HCID 22347243tert-butyl 4-[(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]-4-hydroxy-1-piperidinecarboxylate

Sources & evidence

ORD record
ord-91bcb62e62164a009ec9dd543ed825e8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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