Hydrochloric Acid → 3-[N-(2-Cyclohexylethyl)amino]propionamide hydrochloride

HRID 11438Notes

Reaction equation

HRID 11438 reaction equation
[ClH:1].C(OC([N:9]([CH2:18][CH2:19][C:20]([NH2:22])=[O:21])[CH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[CH:12]1([CH2:11][CH2:10][NH:9][CH2:18][CH2:19][C:20]([NH2:22])=[O:21])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 121366253-[N-(t-butoxycarbonyl)-N-(2-cyclohexylethyl)amino]propionamide

Product 1

HCID 219741893-[N-(2-Cyclohexylethyl)amino]propionamide hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Next, a 4 N solution of hydrogen chloride in 1,4-dioxane (3.1 ml) was added to 3-[N-(t-butoxycarbonyl)-N-(2-cyclohexylethyl)amino]propionamide (0.37 g, 1.2 mmol), and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, diisopropyl ether was added to the resulting solid, and the solid was filtered off to give 0.30 g (quantitatively) of the titled compound as colorless crystals.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure, diisopropyl ether
  2. additionwas added to the resulting solid
  3. filtrationthe solid was filtered off

Sources & evidence

ORD record
ord-58a7af91c94048528b7c9e20557128a1
Source dataset
uspto-grants-2006_08
Patent number
US07098226B2

Reaction notes

Loading…