Dichloromethane → Tert-butyl 4-(acetyloxymethyl)-3-hydroxypiperidine-1-carboxylate

HRID 1145561Notes

Reaction equation

[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([OH:16])[CH:11]([CH2:14][OH:15])[CH2:12][CH2:13]1.[CH3:17][CH2:18][N:19]([CH2:20][CH3:21])[CH2:22][CH3:23].[CH3:24][C:25](=[O:26])[O:27][C:28](=[O:29])[CH3:30].[Cl:31][CH2:32][Cl:33]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([OH:16])[CH:11]([CH2:14][O:15][C:25]([CH3:24])=[O:26])[CH2:12][CH2:13]1

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 7918Acetic Anhydride

HCID 8471Triethylamine

HCID 154810601,1-Dimethylethyl 3-hydroxy-4-(hydroxymethyl)-1-piperidinecarboxylate

Product 1

HCID 67387621Tert-butyl 4-(acetyloxymethyl)-3-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record: ord-a0178a32ce8343ec8d049df04fc677a6
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…