Methanol → N-(2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide

HRID 1145909Notes

Reaction equation

HRID 1145909 reaction equation
[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:41][OH:42].[NH2:39][NH2:40].[O:1]=[C:2]1[N:3]([CH2:12][CH:13]([CH2:14][c:15]2[c:16]([C:21]([F:22])([F:23])[F:24])[cH:17][cH:18][cH:19][cH:20]2)[NH:25][C:26](=[O:27])[c:28]2[s:29][c:30](-[c:33]3[cH:34][cH:35][n:36][n:37]3[CH3:38])[cH:31][cH:32]2)[C:10](=[O:11])[c:5]2[c:4]1[cH:9][cH:8][cH:7][cH:6]2>>[NH2:3][CH2:12][CH:13]([CH2:14][c:15]1[c:16]([C:21]([F:22])([F:23])[F:24])[cH:17][cH:18][cH:19][cH:20]1)[NH:25][C:26](=[O:27])[c:28]1[s:29][c:30](-[c:33]2[cH:34][cH:35][n:36][n:37]2[CH3:38])[cH:31][cH:32]1

Participants

5

Reactant 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 9321HydrazineHCID 76576432N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-5-(2-methylpyrazol-3-yl)thiophene-2-carboxamide

Product 1

HCID 67066052N-(2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide

Sources & evidence

ORD record
ord-a71afbefd7c140cc933cedb62735a3a1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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