Dichloromethane → 1-(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)-2-methoxyethanone tetrahydrochloride

HRID 1146340Notes

Reaction equation

HRID 1146340 reaction equation
[CH2:34]([N:35]([CH:36]([CH3:37])[CH3:38])[CH:39]([CH3:40])[CH3:41])[c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1.[CH2:51]1[O:52][CH2:53][CH2:54][CH2:55]1.[CH3:1][O:2][CH2:3][C:4](=[O:5])[Cl:6].[Cl:48][CH2:49][Cl:50].[o:7]1[c:8](-[c:16]2[c:17]([NH2:33])[n:18][cH:19][c:20](-[c:22]3[cH:23][n:24][n:25]([CH:27]4[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]4)[cH:26]3)[cH:21]2)[n:9][c:10]2[c:11]1[cH:12][cH:13][cH:14][cH:15]2>>[CH3:1][O:2][CH2:3][C:4](=[O:5])[N:30]1[CH2:29][CH2:28][CH:27]([n:25]2[n:24][cH:23][c:22](-[c:20]3[cH:19][n:18][c:17]([NH2:33])[c:16](-[c:8]4[o:7][c:11]5[c:10]([n:9]4)[cH:15][cH:14][cH:13][cH:12]5)[cH:21]3)[cH:26]2)[CH2:32][CH2:31]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 96623Methoxyacetyl chlorideHCID 4578032BenzyldiisopropylamineHCID 441601373-(1,3-Benzoxazol-2-yl)-5-[1-(4-piperidyl)pyrazol-4-yl]pyridin-2-amine

Product 1

HCID 497984811-(4-(4-(6-amino-5-(benzo[d]oxazol-2-yl)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)-2-methoxyethanone tetrahydrochloride

Sources & evidence

ORD record
ord-d2ebe35c6c094492a6e659c8c0f266d2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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