Potassium Cation → 4-[6-Butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxymethyl]-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester

HRID 1146375Notes

Reaction equation

HRID 1146375 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH2:14][OH:15])([F:16])[CH2:12][CH2:13]1.[CH2:23]([CH2:24][CH2:25][CH3:26])[c:27]1[n:28][n:29][c:30]([Cl:46])[cH:31][c:32]1-[c:33]1[cH:34][cH:35][c:36]([O:39][CH:40]2[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45]2)[cH:37][cH:38]1.[CH2:47]1[O:48][CH2:49][CH2:50][CH2:51]1.[CH3:17][C:18]([CH3:19])([O-:20])[CH3:21].[K+:22]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH2:14][O:15][c:30]2[n:29][n:28][c:27]([CH2:23][CH2:24][CH2:25][CH3:26])[c:32](-[c:33]3[cH:34][cH:35][c:36]([O:39][CH:40]4[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45]4)[cH:37][cH:38]3)[cH:31]2)([F:16])[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 813Potassium CationHCID 8028TetrahydrofuranHCID 45749132-Methylpropan-2-olateHCID 22248400tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylateHCID 866577793-Butyl-6-chloro-4-(4-cyclohexyloxy-phenyl)-pyridazine

Product 1

HCID 673744624-[6-Butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxymethyl]-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-066588ff38734473a4929c414dfd9240
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…