Hydrochloric Acid → HCID 21973956, compound

HRID 11464Notes

Reaction equation

HRID 11464 reaction equation
[C:1]12([CH2:11][CH2:12][N:13]([CH2:26][CH2:27][N:28](C(OC(C)(C)C)=O)[CH3:29])[C:14]([NH:16][CH2:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)=[O:15])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[ClH:37]>CO>[ClH:37].[ClH:37].[C:1]12([CH2:11][CH2:12][N:13]([CH2:26][CH2:27][NH:28][CH3:29])[C:14]([NH:16][CH2:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)=[O:15])[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH2:2]1)[CH2:10]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10228693HCID 10228693, compound

Product 1

HCID 21973956HCID 21973956, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Methanol (4.4 ml) was added to 1-[2-(1-adamantyl)ethyl]-1-[2-[N-(t-butoxycarbonyl)-N-methylamino]ethyl]-3-[3-(4-pyridyl)propyl]urea (Compound No. 1-26) (0.30 g, 0.6 mmol), a calcium chloride tube was attached to the vessel, and the mixture was stirred at room temperature. A 10% solution of hydrogen chloride in methanol (4.4 ml) was added to the mixture, the whole was stirred for one day, and the reaction mixture was concentrated under reduced pressure to give 0.30 g (quantitatively) of the titled compound as pale yellow noncrystalline powder.

Workup

  1. stirringthe whole was stirred for one day
  2. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0a0971544254491fb73c8a18d6027388
Source dataset
uspto-grants-2006_08
Patent number
US07098226B2

Reaction notes

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