Hydrochloric Acid → 1'-[(5-fluoropyridin-3-yl)methyl]-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

HRID 1146533Notes

Reaction equation

HRID 1146533 reaction equation
[CH3:54][c:55]1[cH:56][cH:57][c:58]([S:59]([O:60][CH2:61][CH:62]2[CH2:63][O:64][CH2:65][CH2:66][O:67]2)(=[O:68])=[O:69])[cH:70][cH:71]1.[Cl:45][CH2:46][c:47]1[cH:48][n:49][cH:50][c:51]([F:53])[cH:52]1.[ClH:44].[NH:1]1[C:2](=[O:22])[C:3]2([CH2:4][O:5][c:6]3[cH:7][c:8]4[c:9]([cH:14][c:15]32)[O:10][CH2:11][CH2:12][O:13]4)[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21.[NH:23]1[c:24]2[c:25]([cH:26][cH:27][cH:28][cH:29]2)[C:30]2([c:31]3[cH:32][c:33]4[c:37]([cH:38][c:39]3[O:40][CH2:41]2)[O:36][CH2:35][O:34]4)[C:42]1=[O:43]>>[N:1]1([CH2:46][c:47]2[cH:48][n:49][cH:50][c:51]([F:53])[cH:52]2)[C:2](=[O:22])[C:3]2([CH2:4][O:5][c:6]3[cH:7][c:8]4[c:9]([cH:14][c:15]32)[O:10][CH2:11][CH2:12][O:13]4)[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 216984253-(Chloromethyl)-5-fluoropyridineHCID 53375495spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-oneHCID 53966326(+/-)-(1,4-Dioxan-2-YL)methyl 4-methylbenzenesulfonateHCID 58224164Spiro[furo[2,3-g]-1,4-benzodioxin-8(7H),3'-[3H]indol]-2'(1'H)-one, 2,3-dihydro

Product 1

HCID 593524761'-[(5-fluoropyridin-3-yl)methyl]-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-068ec4f092914eb3a14c996f7d3db65f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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