1,4-Dioxane → 8-(2-Chloro-4-fluorophenyl)-N-(1-(2-methylpyridin-4-yl)piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

HRID 1146777Notes

Reaction equation

HRID 1146777 reaction equation
[Br:25][c:26]1[cH:27][c:28]([CH3:32])[n:29][cH:30][cH:31]1.[CH2:42]1[O:43][CH2:44][CH2:45][O:46][CH2:47]1.[CH:33]([N:34]([CH2:35][CH3:36])[CH:37]([CH3:38])[CH3:39])([CH3:40])[CH3:41].[Cl:1][c:2]1[c:3](-[c:9]2[c:10]3[n:11]([cH:12][cH:13][cH:14]2)[n:15][c:16]([NH:18][CH:19]2[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]2)[n:17]3)[cH:4][cH:5][c:6]([F:8])[cH:7]1>>[Cl:1][c:2]1[c:3](-[c:9]2[c:10]3[n:11]([cH:12][cH:13][cH:14]2)[n:15][c:16]([NH:18][CH:19]2[CH2:20][CH2:21][N:22]([c:26]4[cH:27][c:28]([CH3:32])[n:29][cH:30][cH:31]4)[CH2:23][CH2:24]2)[n:17]3)[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

5

Reactant 4

HCID 312751,4-DioxaneHCID 81531DiisopropylethylamineHCID 27628354-Bromo-2-methylpyridineHCID 67342842HCID 67342842, compound

Product 1

HCID 533538138-(2-Chloro-4-fluorophenyl)-N-(1-(2-methylpyridin-4-yl)piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Sources & evidence

ORD record
ord-a0bfc338601c452cb9e029a0d9cc1e13
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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