Hydrochloric Acid → 3-(5,8-Difluoro-3,4-dihydro-1H-isoquinolin-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine

HRID 114695Notes

Reaction equation

HRID 114695 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([n:14]2[n:15][cH:16][c:17](-[c:19]3[cH:20][n:21][c:22]([NH2:37])[c:23]([N:25]4[CH2:26][c:27]5[c:28]([F:36])[cH:29][cH:30][c:31]([F:35])[c:32]5[CH2:33][CH2:34]4)[cH:24]3)[cH:18]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH3:39][OH:40].[CH3:41][CH2:42][O:43][CH2:44][CH3:45].[ClH:38]>>[NH:8]1[CH2:9][CH2:10][CH:11]([n:14]2[n:15][cH:16][c:17](-[c:19]3[cH:20][n:21][c:22]([NH2:37])[c:23]([N:25]4[CH2:26][c:27]5[c:28]([F:36])[cH:29][cH:30][c:31]([F:35])[c:32]5[CH2:33][CH2:34]4)[cH:24]3)[cH:18]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3283Diethyl EtherHCID 67520643HCID 67520643, compound

Product 1

HCID 675211263-(5,8-Difluoro-3,4-dihydro-1H-isoquinolin-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine

Sources & evidence

ORD record
ord-d8a349aa8ac64689ae75d563b742e60c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…