Ethyl Acetate → Sorafenib

HRID 1147043Notes

Reaction equation

HRID 1147043 reaction equation
[CH3:33][CH2:34][O:35][C:36](=[O:37])[CH3:38].[Cl:19][c:20]1[c:21]([C:29]([F:30])([F:31])[F:32])[cH:22][c:23]([N:26]=[C:27]=[O:28])[cH:24][cH:25]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([O:6][c:7]2[cH:8][c:9]([C:13](=[O:14])[NH:15][CH3:16])[n:10][cH:11][cH:12]2)[cH:17][cH:18]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([O:6][c:7]2[cH:8][c:9]([C:13](=[O:14])[NH:15][CH3:16])[n:10][cH:11][cH:12]2)[cH:17][cH:18]1)[C:27]([NH:26][c:23]1[cH:22][c:21]([C:29]([F:30])([F:31])[F:32])[c:20]([Cl:19])[cH:25][cH:24]1)=[O:28]

Participants

4

Reactant 3

HCID 8857Ethyl AcetateHCID 27332651-Chloro-4-isocyanato-2-(trifluoromethyl) benzeneHCID 166551294-(4-Aminophenoxy)-N-methylpicolinamide

Product 1

HCID 216239Sorafenib

Sources & evidence

ORD record
ord-5c5994306e054c798fea251190f1028b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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