Hydrochloric Acid → 6-(3,3-Difluoro-azetidin-1-yl)-N-(3-iodo-4-methyl-phenyl)-nicotinamide

HRID 1147475Notes

Reaction equation

HRID 1147475 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([C:6](=[O:7])[NH:8][c:9]2[cH:10][c:11]([I:16])[c:12]([CH3:15])[cH:13][cH:14]2)[cH:17][cH:18]1.[ClH:19].[F:20][C:21]1([F:25])[CH2:22][NH:23][CH2:24]1.[I:26][c:27]1[cH:28][c:29]([NH:30][C:31](=[O:32])[c:33]2[cH:34][cH:35][c:36]([N:37]3[CH2:38][CH2:39][O:40][CH2:41][CH2:42]3)[n:43][cH:44]2)[cH:45][cH:46][c:47]1[CH3:48]>>[c:2]1([N:23]2[CH2:22][C:21]([F:20])([F:25])[CH2:24]2)[n:3][cH:4][c:5]([C:6](=[O:7])[NH:8][c:9]2[cH:10][c:11]([I:16])[c:12]([CH3:15])[cH:13][cH:14]2)[cH:17][cH:18]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 27582483,3-DifluoroazetidineHCID 79255626-chloro-N-(3-iodo-4-methyl-phenyl)-nicotinamideHCID 17541675N-(3-Iodo-4-methyl-phenyl)-6-morpholin-4-yl-nicotinamide

Product 1

HCID 593181306-(3,3-Difluoro-azetidin-1-yl)-N-(3-iodo-4-methyl-phenyl)-nicotinamide

Sources & evidence

ORD record
ord-c69bcce5bdff42439ce350dcda876b60
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…