Pyridine → Tert-butyl 2-cyano-4-hydroxy-pyrrolidine-1-carboxylate

HRID 1148456Notes

Reaction equation

HRID 1148456 reaction equation
[C:1]([NH2:2])(=[O:3])[CH:4]1[N:5]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[CH2:6][CH:7]([OH:9])[CH2:8]1.[F:17][C:18]([F:19])([F:20])[C:21]([O:22][C:23](=[O:24])[C:25]([F:26])([F:27])[F:28])=[O:29].[cH:30]1[cH:31][cH:32][n:33][cH:34][cH:35]1>>[C:1](#[N:2])[CH:4]1[N:5]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[CH2:6][CH:7]([OH:9])[CH2:8]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 9845Trifluoroacetic anhydrideHCID 14796647Tert-butyl 2-carbamoyl-4-hydroxypyrrolidine-1-carboxylate

Product 1

HCID 68626765Tert-butyl 2-cyano-4-hydroxy-pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-38a2a8a5bae4436ea8fe935f3585fc5a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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