Methanol → tert-Butyl 4-(hydroxymethyl)-4-methoxypiperidine-1-carboxylate

HRID 1149205Notes

Reaction equation

HRID 1149205 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]2([CH2:12][O:13]2)[CH2:14][CH2:15]1.[CH3:28][OH:29].[OH2:16].[c:17]1([CH3:18])[cH:19][cH:20][c:21]([S:22]([OH:23])(=[O:24])=[O:25])[cH:26][cH:27]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH2:12][OH:16])([O:13][CH3:28])[CH2:14][CH2:15]1

Participants

5

Reactant 4

HCID 887MethanolHCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 22135564tert-Butyl 1-oxa-6-azaspiro(2.5)octane-6-carboxylate

Product 1

HCID 23447302tert-Butyl 4-(hydroxymethyl)-4-methoxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-39bd9ec40ea349c8813bd8e21c5c1d2d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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