p-Bromochlorobenzene → 4-(4-Chloro-phenyl)-4-hydroxy-3,3-dimethyl-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([Cl:8])[cH:6][cH:7]1.[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH2:9]([Li:10])[CH2:11][CH2:12][CH3:13].[CH3:14][C:15]1([CH3:29])[CH2:16][N:17]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:18][CH2:19][C:20]1=[O:21]>>[c:2]1([C:20]2([OH:21])[C:15]([CH3:14])([CH3:29])[CH2:16][N:17]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:18][CH2:19]2)[cH:3][cH:4][c:5]([Cl:8])[cH:6][cH:7]1Participants
5
Sources & evidence
- ORD record
- ord-821228765ce249d8ac4641bb050a32f8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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