Hydrochloric Acid → 2-Methyl-1-(piperidin-4-yl)piperidine

HRID 1150179Notes

Reaction equation

HRID 1150179 reaction equation
[C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])(=[O:20])[N:21]1[CH2:22][CH2:23][CH:24]([N:27]2[CH:28]([CH3:33])[CH2:29][CH2:30][CH2:31][CH2:32]2)[CH2:25][CH2:26]1.[CH3:3][CH:4]1[CH2:5][CH2:6][CH2:7][N:8]1[CH:9]1[CH2:10][CH2:11][NH:12][CH2:13]1.[ClH:1].[ClH:2].[O-:34][S:35]([c:36]1[cH:37][cH:38][c:39]([CH3:40])[cH:41][cH:42]1)(=[O:43])=[O:44]>>[NH:21]1[CH2:22][CH2:23][CH:24]([N:27]2[CH:28]([CH3:33])[CH2:29][CH2:30][CH2:31][CH2:32]2)[CH2:25][CH2:26]1

Participants

5

Reactant 4

HCID 313Hydrochloric Acid2×HCID 85570p-ToluenesulfonateHCID 534010602-Methyl-1-pyrrolidin-3-ylpyrrolidineHCID 77289605Tert-butyl 4-(2-methylpiperidin-1-yl)piperidine-1-carboxylate

Product 1

HCID 230920632-Methyl-1-(piperidin-4-yl)piperidine

Sources & evidence

ORD record
ord-dc32237221254f6ebed3d8bf006c5289
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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